Should my B2B brand be on Nextdoor?

For B2B, almost never. Nextdoor is a neighborhood platform built around local services, home improvement, real estate, childcare, and the kind of thing a resident asks a neighbor about. 

If you have physical locations serving consumers in specific markets, a claimed business page and some review activity is worth a small amount of time. 

If you sell software or services to companies across the country, skip it and put the time into LinkedIn.